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KMID : 0352720130370040435
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Journal of Ginseng Research
2013 Volume.37 No. 4 p.435 ~ p.441
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Effect of Korean Red Ginseng on radiation-induced bone loss in C3H/HeN mice
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Lee Jin-Hee
Lee Hae-June
Yang Mi-Young
Moon Chang-Jong
Kim Jong-Choon
Bae Chun-Sik
Jo Sung-Kee
Jang Jong-Sik
Kim Sung-Ho
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Abstract
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This study investigated the effects of Korean Red Ginseng (KRG) on radiation-induced bone loss in C3H/HeN mice. C3H/HeN mice were divided into sham and irradiation (3 Gy, gamma-ray) groups. The irradiated mice were treated for 12 wk with vehicle, KRG (per os, p.o.) or KRG (intraperitoneal). Serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase, estradiol level, and biomechanical properties were measured. Tibiae were analyzed using micro-computed tomography. Treatment of KRG (p.o., 250 mg/kg of body weight/d) significantly preserved trabecular bone volume, trabecular number, structure model index, and bone mineral density of proximal tibia metaphysic, but did not alter the uterus weight of the mice. Serum ALP level was slightly reduced by KRG treatment. However, grip strength, mechanical property, and cortical bone architecture did not differ among the experimental groups. The results indicate that KRG can prevent radiation-induced bone loss in mice.
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KEYWORD
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Panax ginseng, Korean Red Ginseng, Radiation, Bone loss, Trabecular bone,
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